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GWAS results and power simulationsWe found no evidence of association significant at a genome wide level of P 10 a Manhattan plot from analysis of set 1 is shown as an example in Figure 1. The lowest P value in set 1 (2.89 10 was found at rs883565 (chromosome 3), and the lowest value in set 2 was 3.83 10 at rs296859 (chromosome 9). There was no significant evidence of association with alleles in a region surrounding LRRTM1 on chromosome 2 previously implicated in association with relative hand skill.
Ultimately, all trials were meta analysed to give an overall picture of the effect of delivery of a physiotherapy intervention versus no physiotherapy intervention. Publications were assessed for methodological quality by recording specified eligibility criteria, method of randomisation and blinding, concealment of allocation, similarity of patients in treatment groups at baseline, variation in cointerventions received by patients throughout the trial period, whether an intention to treat analysis was performed, and the number of patients lost to follow up.Quantitative data synthesisOutcome data included gait outcomes (such as the two or six min walk test, 10 or 20 m walk test, speed, cadence, stride and step length, freezing of gait questionnaire), functional mobility and balance outcomes (such as the timed up and go test, functional reach test, Berg balance scale, activities specific balance confidence scale), falls data (such as number of falls, falls efficacy scale), clinician rated disability scales (such as the unified Parkinson's disease rating scale (UPDRS)), patient rated quality of life (such as Parkinson's disease questionnaire 39), adverse events, compliance or withdrawals, and health economics where available.Results of each trial were combined using standard meta analytic methods to estimate an overall effect for physiotherapy versus no intervention. Since all outcomes were continuous variables, weighted mean difference methods were used.23 Briefly, for each trial, this involved calculating the mean change (and standard deviation) from baseline to the time point after intervention, for both the intervention and no intervention groups.Guys!RSorder 2017 Spring Bonus Boom :Up to 10% Extra bonus for rs3 gold and rs 2007 gold buying from http://www.rsorder.c...-school-rs-gold During April 21- May 10, 2017!
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